Nafcillin sodium salt monohydrate

• Catalog No.: N3269
• CAS Number: 7177-50-6
• M. F.: C21H23N2NaO6S
• M. W.: 454.47189

SYNONYMS

• IUPAC name: sodium (2S,5R,6R)-6-(2-ethoxynaphthalene-1-amido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate
• IUPAC Traditional name: sodium nafcillin(1-) hydrate
• Synonyms: 6-(2-Ethoxy-1-naphthamido)penicillin

DATABASE IDS

• PubChem SID: 24897636
• MDL Number: MFCD01941128
• CAS Number: 7177-50-6

PROPERTIES

• Impurities: ~3.5% Sodium citrate
• Linear Formula: C21H21N2O5SNa · H2O
• GHS Signal Word: Danger
• GHS Hazard statements: H315-H317-H319-H334-H335
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P280-P305 + P351 + P338-P342 + P311
• Risk Statements: 36/37/38-42/43
• Safety Statements: 26-36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Application
Nafcillin sodium is a narrow-spectrum β-lactam antibiotic. It is used to treat infections caused by Gram-positive bacteria, in particular, species of Staphylococci that are resistant to other penicillins. Nafcillin is used to study penicillin binding proteins (PBPs). It has been used to study penicillin-binding proteins 2a and heterogeneous expression of methicillin resistance in Staphylococcus aureus 1. It is a potential therapy of meningitis due to Staphylococcus aureus.2.
Biochem/physiol Actions
Nafcillin inhibits bacterial cell wall formation by inhibiting PBPs. The irreversible inhibition of the PBPs prevents the final crosslinking (transpeptidation) of the nascent peptidoglycan layer, which disrupts cell wall synthesis.

Description (简体中文)

Application
Nafcillin sodium is a narrow-spectrum β-lactam antibiotic. It is used to treat infections caused by Gram-positive bacteria, in particular, species of Staphylococci that are resistant to other penicillins. Nafcillin is used to study penicillin binding proteins (PBPs). It has been used to study penicillin-binding proteins 2a and heterogeneous expression of methicillin resistance in Staphylococcus aureus 1. It is a potential therapy of meningitis due to Staphylococcus aureus.2.
Biochem/physiol Actions
Nafcillin inhibits bacterial cell wall formation by inhibiting PBPs. The irreversible inhibition of the PBPs prevents the final crosslinking (transpeptidation) of the nascent peptidoglycan layer, which disrupts cell wall synthesis.