DL-Propargylglycine

• Catalog No.: P7888
• CAS Number: 64165-64-6
• M. F.: C5H7NO2
• M. W.: 113.11458

SYNONYMS

• IUPAC name: 2-aminopent-4-ynoic acid
• IUPAC Traditional name: propargylglycine
• Synonyms: 2-Amino-4-pentynoic acid; PAG

DATABASE IDS

• MDL Number: MFCD00056728
• CAS Number: 64165-64-6
• PubChem SID: 24898885

PROPERTIES

• Empirical Formula (Hill Notation): C5H7NO2
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
DL-Propargylglycine (PAG) is an irreversible inhibitor of the enzyme cystathionine γ-lyase (GCL), a key enzyme involved in glutathione synthesis1 and the metabolic transsulfuration pathway which regulates homocysteine concentration and mediates cysteine synthesis.2 Treatment of animal disease models with PAG was shown to alleviate symptoms of diseases that impair the formation or action of hydrogen sulfide (H2S).3,4

Description (简体中文)

Biochem/physiol Actions
DL-Propargylglycine (PAG) is an irreversible inhibitor of the enzyme cystathionine γ-lyase (GCL), a key enzyme involved in glutathione synthesis1 and the metabolic transsulfuration pathway which regulates homocysteine concentration and mediates cysteine synthesis.2 Treatment of animal disease models with PAG was shown to alleviate symptoms of diseases that impair the formation or action of hydrogen sulfide (H2S).3,4