Oxytetracycline dihydrate

• Catalog No.: O4636
• CAS Number: 6153-64-6
• M. F.: C22H26N2O10
• M. W.: 478.44924
• Purity: ≥99% (TLC)

SYNONYMS

• Title: 土霉素 二水合物
• IUPAC name: (4S,4aR,5S,5aR,6S,12aS)-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrate
• IUPAC Traditional name: oxytetracycline hydrate

DATABASE IDS

• MDL Number: MFCD00151234
• PubChem SID: 24898000
• EC Number: 201-212-8
• CAS Number: 6153-64-6

PROPERTIES

• Antion Traces: chloride (Cl-): ≤0.05%
• Antion Traces: sulfate (SO42-): ≤0.05%
• Cation Traces: Al: ≤0.001%
• Cation Traces: Ca: ≤0.2%
• Cation Traces: Cu: ≤0.0005%
• Cation Traces: Fe: ≤0.002%
• Cation Traces: K: ≤0.005%
• Cation Traces: Mg: ≤0.005%
• Cation Traces: Na: ≤0.01%
• Cation Traces: Pb: ≤0.001%
• Cation Traces: Zn: ≤0.0005%
• Empirical Formula (Hill Notation): C22H24N2O9 · 2H2O
• Ignition Residue: ≤1.0%
• Impurities: ≤0.001% Phosphorus (P)
• Impurities: ≤0.1% Insoluble matter
• Product Line: BioXtra
• Purity: ≥99% (TLC)
• Solubility: 1 M HCl: soluble0.1 M, clear (yellow to yellow-orange)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Antibiotic produced by Streptomyces rimosus.Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.Mode of Resistance: Active efflux, ribosome protection, tetracycline inactivation.
Oxytetracycline inhibits translation, which results in cell death. It binds to the 30S ribosomal subunit and prevents the amino-acyl Trna from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic so it can easily pass through a cell membrane and passively diffuses through channels in the bacterial membrane.
Application
Oxytetracycline is a tetracycline analog isolated from the actinomycete Streptomyces rimosus. Oxytetracycline is an antibiotic indicated for treatment of infections caused by Gram positive and Gram negative microorganisms such as Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae, and Diplococcus pneumoniae. It is used in studies on the oxytetracycline-resistance gene (otrA). It is used for fluorescence measurements of hepatocytes1.

Description (简体中文)

Biochem/physiol Actions
Antibiotic produced by Streptomyces rimosus.Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.Mode of Resistance: Active efflux, ribosome protection, tetracycline inactivation.
Oxytetracycline inhibits translation, which results in cell death. It binds to the 30S ribosomal subunit and prevents the amino-acyl Trna from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic so it can easily pass through a cell membrane and passively diffuses through channels in the bacterial membrane.
Application
Oxytetracycline is a tetracycline analog isolated from the actinomycete Streptomyces rimosus. Oxytetracycline is an antibiotic indicated for treatment of infections caused by Gram positive and Gram negative microorganisms such as Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae, and Diplococcus pneumoniae. It is used in studies on the oxytetracycline-resistance gene (otrA). It is used for fluorescence measurements of hepatocytes1.