8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphate sodium salt

• Catalog No.: C5438
• CAS Number: 51239-26-0
• M. F.: C16H14ClN5NaO7PS
• M. W.: 509.793191
• Purity: ~95% (HPLC)

SYNONYMS

• IUPAC name: sodium (4aR,6R,7R,7aS)-6-{2-amino-8-[(4-chlorophenyl)sulfanyl]-6-oxo-6,9-dihydro-1H-purin-9-yl}-7-hydroxy-2-oxo-hexahydro-1,3,5,2λ^5-furo[3,2-d][1,3,2λ^5]dioxaphosphinin-2-olate
• IUPAC Traditional name: sodium (4aR,6R,7R,7aS)-6-{2-amino-8-[(4-chlorophenyl)sulfanyl]-6-oxo-1H-purin-9-yl}-7-hydroxy-2-oxo-tetrahydro-4H-1,3,5,2λ^5-furo[3,2-d][1,3,2λ^5]dioxaphosphinin-2-olate
• Synonyms: pCPT-cGMP; 8-pCPT-cGMP

DATABASE IDS

• MDL Number: MFCD00674888
• PubChem SID: 24892786
• CAS Number: 51239-26-0

PROPERTIES

• Empirical Formula (Hill Notation): C16H14ClN5NaO7PS
• Purity: ~95% (HPLC)
• Apperance: white powder
• Solubility: H2O: soluble25 mg/mL
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Membrane-permeable analog of cGMP that does not affect cGMP-regulated phosphodiesterase. A more potent cGMP analog than 8-Br-cGMP due to greater membrane permeability and a higher resistance to hydrolysis by phosphodiesterase. Used as a selective activator of cGMP dependent protein kinase (PKG). Found to be a very potent cyclic nucleotide-gated channel agonist.

Description (简体中文)

Biochem/physiol Actions
Membrane-permeable analog of cGMP that does not affect cGMP-regulated phosphodiesterase. A more potent cGMP analog than 8-Br-cGMP due to greater membrane permeability and a higher resistance to hydrolysis by phosphodiesterase. Used as a selective activator of cGMP dependent protein kinase (PKG). Found to be a very potent cyclic nucleotide-gated channel agonist.