Cytosine β-D-arabinofuranoside hydrochloride

• Catalog No.: C6645
• CAS Number: 69-74-9
• M. F.: C9H14ClN3O5
• M. W.: 279.67756

SYNONYMS

• Title: 胞嘧啶β-D-呋喃阿拉伯糖苷 盐酸盐
• IUPAC name: 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one hydrochloride
• IUPAC Traditional name: cytarabine hydrochloride
• Synonyms: Arabinosylcytosine hydrochloride; 阿糖胞嘧啶 盐酸盐; 1-(β-D-呋喃阿拉伯糖苷)-胞嘧啶 盐酸盐; Cytosine Arabinoside Hydrochloride; Arabinocytidine hydrochloride; 1-(β-D-Arabino-furanosyl)-cytosine hydrochloride; Ara-C hydrochloride; Ara-C 盐酸盐; 胞嘧啶阿拉伯糖苷 盐酸盐; 阿拉伯糖胞嘧啶 盐酸盐; 阿糖胞苷 盐酸盐; Cytarabine Hydrochloride

DATABASE IDS

• EC Number: 200-713-9
• CAS Number: 69-74-9
• PubChem SID: 24278329
• MDL Number: MFCD00012839

PROPERTIES

• Empirical Formula (Hill Notation): C9H13N3O5 · HCl
• Apperance: crystalline
• Melting Point: 197-198 °C(lit.)
• GHS Signal Word: Warning
• GHS Hazard statements: H317-H319-H341-H361
• European Hazard Symbols: Harmful (Xn)
• GHS Precautionary statements: P280-P305 + P351 + P338
• Risk Statements: 63-36-43
• Safety Statements: 26-36/37
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Ara-C is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway.1 Does not inhibit RNA synthesis. Anti-leukemia agent.

Description (简体中文)

Biochem/physiol Actions
Ara-C is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway.1 Does not inhibit RNA synthesis. Anti-leukemia agent.