8-Bromo-cyclic adenosine diphosphate ribose

• Catalog No.: B5416
• CAS Number: 151898-26-9
• M. F.: C15H20BrN5O13P2
• M. W.: 620.196522
• Purity: 85% (HPLC)

SYNONYMS

• Title: 8-溴-环二磷酸腺苷核糖
• IUPAC name: (6aR,8R,9R,9aS)-8-(6-amino-8-bromo-9H-purin-9-yl)-2-{[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-4,9-dihydroxy-hexahydro-2H-1,3,5,7,2λ^5,4λ^5-furo[3,2-f][1,3,5,2λ^5,4λ^5]trioxadiphosphocine-2,4-dione
• IUPAC Traditional name: (6aR,8R,9R,9aS)-8-(6-amino-8-bromopurin-9-yl)-2-{[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-4,9-dihydroxy-tetrahydro-6H-1,3,5,7,2λ^5,4λ^5-furo[3,2-f][1,3,5,2λ^5,4λ^5]trioxadiphosphocine-2,4-dione
• Synonyms: Br-cADP-ribose; Br-cADPR

DATABASE IDS

• MDL Number: MFCD00274402
• CAS Number: 151898-26-9

PROPERTIES

• Empirical Formula (Hill Notation): C15H20BrN5O13P2
• Purity: 85% (HPLC)
• Apperance: white lyophilized powder
• Solubility: H2O: soluble5 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
An antagonist of cyclic ADP-ribose (cADPR), and an endogenous metabolite of β-NAD+. cADPR has been shown to regulate calcium release from the endoplasmic and sarcoplasmic reticulum. In cells, cADPR is synthesized by ADP-ribosyl cyclase or CD38, a lymphocyte differentiation antigen.
Preparation Note
Prepared enzymatically
Physical form
Lyophilized powder containing 10-20% sodium phosphate buffer salts

Description (简体中文)

Biochem/physiol Actions
环二磷酸腺苷核糖 (cADPR) 的拮抗剂，β-NAD+ 的内源性代谢物。cADPR 已显示出可调节内质网和肌浆网的钙释放。在细胞中，cADPR 是由 ADP-核糖基环化酶或淋巴细胞分化抗原 CD38 合成。
Preparation Note
酶法制备
Physical form
含 10-20% 磷酸钠缓冲盐的冻干粉