Acetyl-Amyloid β-Protein Fragment 15-20 Amide_Molecular_structure_CAS_189064-06-0)

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Acetyl-Amyloid β-Protein Fragment 15-20 Amide
Catalog No.	A6933	Name	Sigma Aldrich
CAS Number	189064-06-0	Website	http://www.sigmaaldrich.com
M. F.	C42H63N9O8	Telephone	1-800-521-8956
M. W.	822.00512	Fax
Purity	≥97% (HPLC)	Email
Storage		Chembase ID: 155279

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SYNONYMS

IUPAC name

(2S)-N-[(1S)-5-amino-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-methylpropyl]carbamoyl}-3-methylbutyl]carbamoyl}pentyl]-2-acetamidopentanediamide

IUPAC Traditional name

(2S)-N-[(1S)-5-amino-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-methylpropyl]carbamoyl}-3-methylbutyl]carbamoyl}pentyl]-2-acetamidopentanediamide

Synonyms

Ac-QKLVFF-NH2

amyloid blocker

DATABASE IDS

CAS Number	189064-06-0
MDL Number	MFCD17215285

PROPERTIES

Empirical Formula (Hill Notation)	C42H63N9O8
Purity	≥97% (HPLC)
Gene Information	human ... APP(351)
Apperance	white powder
MSDS Link	Download
Personal Protective Equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage Temperature	-20°C
German water hazard class	3

DETAILS

Description (English)

Amino Acid Sequence
Ac-Gln-Lys-Leu-Val-Phe-Phe-NH2
Biochem/physiol Actions
Amyloid plaques characteristic of the Alzheimer brain contain fibrils composed of amyloid beta aggregates. Short peptides containing the sequence KLVFF have been shown to bind specifically to the homologous region in Aβ and are used to prevent full length amyloid fibril formation.

Description (简体中文)