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Ethambutol dihydrochloride_Molecular_structure_CAS_1070-11-7)
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Ethambutol dihydrochloride

Catalog No. E4630 Name Sigma Aldrich
CAS Number 1070-11-7 Website http://www.sigmaaldrich.com
M. F. C10H26Cl2N2O2 Telephone 1-800-521-8956
M. W. 277.23164 Fax
Purity Email
Storage Chembase ID: 53545

SYNONYMS

IUPAC name
(2R)-2-[(2-{[(2R)-1-hydroxybutan-2-yl]amino}ethyl)amino]butan-1-ol dihydrochloride
IUPAC Traditional name
(2R)-2-[(2-{[(2R)-1-hydroxybutan-2-yl]amino}ethyl)amino]butan-1-ol dihydrochloride
Synonyms
2,2′-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride
Emb

DATABASE IDS

CAS Number 1070-11-7
EC Number 213-970-7
PubChem SID 24894566
MDL Number MFCD00216025

PROPERTIES

Empirical Formula (Hill Notation) C10H24N2O2 · 2HCl
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H360
European Hazard Symbols Toxic Toxic (T)
MSDS Link Download
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements P201-P308 + P313
Risk Statements 61
RTECS EL3854000
Safety Statements 53-22-36/37/39-45
German water hazard class 3

DETAILS

Description (简体中文)
Application
Ethambutol is an antimycobacterial used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance. It has been used to study multidrug-resistant tuberculosis (MDR-TB) in highest-incidence-rate areas in China.1
Biochem/physiol Actions
Ethambutol is bacteriostatic against actively growing TB bacilli. Mycolic acids attach to the 5′-hydroxyl groups of D-arabinose residues of arabinogalactan and form mycolyl-arabinogalactan-peptidoglycan complex in the cell wall. Ethambutol disrupts arabinogalactan synthesis by inhibiting arabinosyltransferases, specifically those in Mycobacterium, interfering with the biosynthesis of arabinogalactans found in the cell wall of mycobacteria and leading to increased cell wall permeability.2,3
Description (English)
Application
Ethambutol is an antimycobacterial used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance. It has been used to study multidrug-resistant tuberculosis (MDR-TB) in highest-incidence-rate areas in China.1
Biochem/physiol Actions
Ethambutol is bacteriostatic against actively growing TB bacilli. Mycolic acids attach to the 5′-hydroxyl groups of D-arabinose residues of arabinogalactan and form mycolyl-arabinogalactan-peptidoglycan complex in the cell wall. Ethambutol disrupts arabinogalactan synthesis by inhibiting arabinosyltransferases, specifically those in Mycobacterium, interfering with the biosynthesis of arabinogalactans found in the cell wall of mycobacteria and leading to increased cell wall permeability.2,3

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