(±)-PPHT hydrochloride

• Catalog No.: P105
• CAS Number: 71787-90-1
• M. F.: C21H28ClNO
• M. W.: 345.90612
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 6-[(2-phenylethyl)(propyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride
• IUPAC Traditional name: 6-[(2-phenylethyl)(propyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride
• Synonyms: (±)-2-(N-Phenethyl-N-propyl)amino-5-hydroxytetralin hydrochloride; N-0434

DATABASE IDS

• PubChem SID: 24277925
• CAS Number: 71787-90-1
• MDL Number: MFCD00055157

PROPERTIES

• Empirical Formula (Hill Notation): C21H27NO · HCl
• Purity: ≥98% (HPLC)
• Gene Information: human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)
• Apperance: off-white solid
• Solubility: DMSO: ≥10 mg/mL
• Solubility: H2O: ≥2 mg/mL
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Potent D2 dopamine receptor agonist.
A series of new dopamine (DA) receptor agonists, of the 2-aminotetralin group, i.e. N-0434, N-0437 and N-0734 were investigated in both in vivo and in vitro pharmacological test systems. In vivo, the reversal of the gamma-butyrolactone-induced increase in rat central DOPA biosynthesis rate was taken as a measure of presynaptic activity. The homovanillic acid (HVA) decrease, after intraperitoneal and after oral administration of the drugs was also taken as a measure of presynaptic activity. Postsynaptic activity was measured in two behavioural models, i.e. reserpine reversal and stereotypy induction. The effects of (±)-PPHT (N-0434) these drugs on noradrenaline and dopamine turnover (alpha-MpT method) were studied in addition. The results indicate that all three compounds N-0434 ((±)-PPHT), N-0437 and N-0734 are potent and selective DA agonists that lack significant alpha 2 activity.

Description (简体中文)

Biochem/physiol Actions
Potent D2 dopamine receptor agonist.
A series of new dopamine (DA) receptor agonists, of the 2-aminotetralin group, i.e. N-0434, N-0437 and N-0734 were investigated in both in vivo and in vitro pharmacological test systems. In vivo, the reversal of the gamma-butyrolactone-induced increase in rat central DOPA biosynthesis rate was taken as a measure of presynaptic activity. The homovanillic acid (HVA) decrease, after intraperitoneal and after oral administration of the drugs was also taken as a measure of presynaptic activity. Postsynaptic activity was measured in two behavioural models, i.e. reserpine reversal and stereotypy induction. The effects of (±)-PPHT (N-0434) these drugs on noradrenaline and dopamine turnover (alpha-MpT method) were studied in addition. The results indicate that all three compounds N-0434 ((±)-PPHT), N-0437 and N-0734 are potent and selective DA agonists that lack significant alpha 2 activity.