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Phenacetin

Catalog No. DB03783 Name DrugBank
CAS Number 62-44-2 Website http://www.ualberta.ca/
M. F. C10H13NO2 Telephone (780) 492-3111
M. W. 179.21572 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 3432

SYNONYMS

IUPAC name
N-(4-ethoxyphenyl)acetamide
IUPAC Traditional name
phenacetin
Brand Name
Codempiral
Contradol
Contradouleur
Achrocidin
Commotional
Synonyms
Acetophenetidine
Acetophenetidin
Acetophenetin
Acetphenetidin

DATABASE IDS

PubChem CID 4754
PubChem SID 46507394
CAS Number 62-44-2

PROPERTIES

DETAILS

Description (English)
Item Information
Drug Groups experimental; withdrawn
Description Phenacetin was withdrawn from the Canadian market in June 1973 due to concerns regarding nephropathy (damage to or disease of the kidney).
Indication Used principally as an analgesic.
Pharmacology Phenacetin was the first NSAID and fever reducer to go on the market. Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action of the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treat rheumatoid arthritis (subacute type), intercostal neuralgia, and some forms of ataxia. [Wikipedia]
Affected Organisms
Humans and other mammals
References
Dubach UC, Rosner B, Sturmer T: An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987) N Engl J Med. 1991 Jan 17;324(3):155-60. [Pubmed]
Cochran AJ, Lawson DH, Linton AL: Renal papillary necrosis following phenacetin excess. Scott Med J. 1967 Jul;12(7):246-50. [Pubmed]
TAN GH, RABBINO MD, HOPPER J Jr: IS PHENACETIN A NEPHROTOXIN?A REPORT ON TWENTY-THREE USERS OF THE DRUG. Calif Med. 1964 Aug;101:73-7. [Pubmed]
Brix AE: Renal papillary necrosis. Toxicol Pathol. 2002 Nov-Dec;30(6):672-4. [Pubmed]
External Links
Wikipedia

REFERENCES

  • Dubach UC, Rosner B, Sturmer T: An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987) N Engl J Med. 1991 Jan 17;324(3):155-60. Pubmed
  • Brix AE: Renal papillary necrosis. Toxicol Pathol. 2002 Nov-Dec;30(6):672-4. Pubmed
  • Cochran AJ, Lawson DH, Linton AL: Renal papillary necrosis following phenacetin excess. Scott Med J. 1967 Jul;12(7):246-50. Pubmed
  • TAN GH, RABBINO MD, HOPPER J Jr: IS PHENACETIN A NEPHROTOXIN?A REPORT ON TWENTY-THREE USERS OF THE DRUG. Calif Med. 1964 Aug;101:73-7. Pubmed