Application
Phenoxymethylpenicillinic acid, also known as Penicillin V, is narrow spectrum antibiotic used to treat mild to moderate infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered orally. Penicillin V is a penicillin β-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. It is commonly used in cell culture in combination with streptomcyin and other antibiotics. It is used to study penicillin-binding protein 21, molecular cloning of the Bacillus sphaericus penicillin V amidase gene2, and gastrointestinal persistence and bile tolerance of Listeria monocytogenes3.
Biochem/physiol Actions
Phenoxymethylpenicillinic acid binds to specific penicillin-binding proteins (PBPs) and inhibits the synthesis of bacterial cell walls by preventing cell wall peptidoglycan chain cross-linking. This causes cell lysis, which is mediated by autolytic enzymes such as autolysins. Phenoxymethylpenicillnic acid may interfere with autolysin inhibitors.
Phenoxymethylpenicillinic acid inhibits the synthesis of bacterial cell walls by preventing cell wall peptidoglycan chain cross-linking. It is commonly used in cell culture in combination with streptomcyin and other antibiotics. |
Application
Phenoxymethylpenicillinic acid, also known as Penicillin V, is narrow spectrum antibiotic used to treat mild to moderate infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered orally. Penicillin V is a penicillin β-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. It is commonly used in cell culture in combination with streptomcyin and other antibiotics. It is used to study penicillin-binding protein 21, molecular cloning of the Bacillus sphaericus penicillin V amidase gene2, and gastrointestinal persistence and bile tolerance of Listeria monocytogenes3.
Biochem/physiol Actions
Phenoxymethylpenicillinic acid binds to specific penicillin-binding proteins (PBPs) and inhibits the synthesis of bacterial cell walls by preventing cell wall peptidoglycan chain cross-linking. This causes cell lysis, which is mediated by autolytic enzymes such as autolysins. Phenoxymethylpenicillnic acid may interfere with autolysin inhibitors.
Phenoxymethylpenicillinic acid inhibits the synthesis of bacterial cell walls by preventing cell wall peptidoglycan chain cross-linking. It is commonly used in cell culture in combination with streptomcyin and other antibiotics. |