Erythromycin ethyl succinate

• Catalog No.: E8755
• CAS Number: 1264-62-6
• M. F.: C43H75NO16
• M. W.: 862.0527

SYNONYMS

• IUPAC name: 4-(dimethylamino)-2-({14-ethyl-7,12,13-trihydroxy-4-[(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy]-3,5,7,9,11,13-hexamethyl-2,10-dioxo-1-oxacyclotetradecan-6-yl}oxy)-6-methyloxan-3-yl 1-ethyl butanedioate
• IUPAC Traditional name: erythromycin ethylsuccinate

DATABASE IDS

• EC Number: 215-033-8
• PubChem SID: 24894684
• MDL Number: MFCD00084692
• CAS Number: 1264-62-6

PROPERTIES

• GHS Precautionary statements: P261-P280-P342 + P311
• Risk Statements: 42/43
• RTECS: WM9800000
• Safety Statements: 36
• German water hazard class: 2
• GHS Signal Word: Danger
• GHS Hazard statements: H317-H334
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• Empirical Formula (Hill Notation): C43H75NO16

DETAILS

Description (English)

Application
Erythromycin ethyl succinate is used to study erythromycin-resistant Streptococcus pyogenes and Streptococcus pneumoniae1. It has been used to study down-regulation of motilin receptors on rabbit colon myocytes2 and lethal mutations in outer membrane genes omsA and firA in Salmonella typhimurium3.
Biochem/physiol Actions
Erythromycin ethyl succinate inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site).
Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site) by binding to the 50s subunit of the bacterial 70s rRNA complex.

Description (简体中文)

Application
Erythromycin ethyl succinate is used to study erythromycin-resistant Streptococcus pyogenes and Streptococcus pneumoniae1. It has been used to study down-regulation of motilin receptors on rabbit colon myocytes2 and lethal mutations in outer membrane genes omsA and firA in Salmonella typhimurium3.
Biochem/physiol Actions
Erythromycin ethyl succinate inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site).
Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site) by binding to the 50s subunit of the bacterial 70s rRNA complex.