Chromomycin A3 from Streptomyces griseus

• Catalog No.: C2659
• CAS Number: 7059-24-7
• M. F.: C57H82O26
• M. W.: 1183.24538
• Purity: ≥95% (HPLC)

SYNONYMS

• IUPAC name: (2S,3S,4S)-6-{[(2S,3S,4S)-6-{[(2R,3R,4R)-6-{[(2S,3S)-6-{[(4S,5R,6S)-5-(acetyloxy)-4-{[(4S,5S,6S)-4-hydroxy-5-methoxy-6-methyloxan-2-yl]oxy}-6-methyloxan-2-yl]oxy}-3-[(1R,3S,4S)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-8,9-dihydroxy-7-methyl-1-oxo-1,2,3,4-tetrahydroanthracen-2-yl]oxy}-3-hydroxy-2-methyloxan-4-yl]oxy}-3-hydroxy-2-methyloxan-4-yl]oxy}-4-hydroxy-2,4-dimethyloxan-3-yl acetate
• IUPAC Traditional name: (2S,3S,4S)-6-{[(2S,3S,4S)-6-{[(2R,3R,4R)-6-{[(2S,3S)-6-{[(4S,5R,6S)-5-(acetyloxy)-4-{[(4S,5S,6S)-4-hydroxy-5-methoxy-6-methyloxan-2-yl]oxy}-6-methyloxan-2-yl]oxy}-3-[(1R,3S,4S)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-8,9-dihydroxy-7-methyl-1-oxo-3,4-dihydro-2H-anthracen-2-yl]oxy}-3-hydroxy-2-methyloxan-4-yl]oxy}-3-hydroxy-2-methyloxan-4-yl]oxy}-4-hydroxy-2,4-dimethyloxan-3-yl acetate

DATABASE IDS

• CAS Number: 7059-24-7
• PubChem SID: 24892514
• MDL Number: MFCD00043151
• EC Number: 230-348-0

PROPERTIES

• Empirical Formula (Hill Notation): C57H82O26
• Purity: ≥95% (HPLC)
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H360
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P264-P301 + P310-P308 + P313
• RID/ADR: UN 3462 6.1/PG 1
• Risk Statements: 61-28
• RTECS: GB7875000
• Safety Statements: 53-28-36/37/39-45
• Storage Temperature: -20°C
• Hazard Class: 6.1
• UN Number: 3462
• Packing Group: 1
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
An antibiotic exhibiting anti-bacterial, anti-fungal and antitumor activities. Serves as a fluorescent DNA stain. Useful for the detection of protamine deficiency in sperm chromatin. The compound blocks macromolecule synthesis by a specific, reversible interaction with DNA in the presence of bivalent metal ions. Binding to DNA minor groove mediates an efficient competitive inhibition of DNA gyrase and significantly affects topoisomerase II activity.

Description (简体中文)

Biochem/physiol Actions
An antibiotic exhibiting anti-bacterial, anti-fungal and antitumor activities. Serves as a fluorescent DNA stain. Useful for the detection of protamine deficiency in sperm chromatin. The compound blocks macromolecule synthesis by a specific, reversible interaction with DNA in the presence of bivalent metal ions. Binding to DNA minor groove mediates an efficient competitive inhibition of DNA gyrase and significantly affects topoisomerase II activity.