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Chromomycin A3 from Streptomyces griseus_Molecular_structure_CAS_7059-24-7)
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Chromomycin A3 from Streptomyces griseus

Catalog No. C2659 Name Sigma Aldrich
CAS Number 7059-24-7 Website http://www.sigmaaldrich.com
M. F. C57H82O26 Telephone 1-800-521-8956
M. W. 1183.24538 Fax
Purity ≥95% (HPLC) Email
Storage Chembase ID: 155131

SYNONYMS

IUPAC name
(2S,3S,4S)-6-{[(2S,3S,4S)-6-{[(2R,3R,4R)-6-{[(2S,3S)-6-{[(4S,5R,6S)-5-(acetyloxy)-4-{[(4S,5S,6S)-4-hydroxy-5-methoxy-6-methyloxan-2-yl]oxy}-6-methyloxan-2-yl]oxy}-3-[(1R,3S,4S)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-8,9-dihydroxy-7-methyl-1-oxo-1,2,3,4-tetrahydroanthracen-2-yl]oxy}-3-hydroxy-2-methyloxan-4-yl]oxy}-3-hydroxy-2-methyloxan-4-yl]oxy}-4-hydroxy-2,4-dimethyloxan-3-yl acetate
IUPAC Traditional name
(2S,3S,4S)-6-{[(2S,3S,4S)-6-{[(2R,3R,4R)-6-{[(2S,3S)-6-{[(4S,5R,6S)-5-(acetyloxy)-4-{[(4S,5S,6S)-4-hydroxy-5-methoxy-6-methyloxan-2-yl]oxy}-6-methyloxan-2-yl]oxy}-3-[(1R,3S,4S)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-8,9-dihydroxy-7-methyl-1-oxo-3,4-dihydro-2H-anthracen-2-yl]oxy}-3-hydroxy-2-methyloxan-4-yl]oxy}-3-hydroxy-2-methyloxan-4-yl]oxy}-4-hydroxy-2,4-dimethyloxan-3-yl acetate

DATABASE IDS

CAS Number 7059-24-7
PubChem SID 24892514
MDL Number MFCD00043151
EC Number 230-348-0

PROPERTIES

Empirical Formula (Hill Notation) C57H82O26
Purity ≥95% (HPLC)
GHS Pictograms GHS06
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H300-H360
European Hazard Symbols Highly toxic Highly toxic (T+)
MSDS Link Download
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements P201-P264-P301 + P310-P308 + P313
RID/ADR UN 3462 6.1/PG 1
Risk Statements 61-28
RTECS GB7875000
Safety Statements 53-28-36/37/39-45
Storage Temperature -20°C
Hazard Class 6.1
UN Number 3462
Packing Group 1
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
An antibiotic exhibiting anti-bacterial, anti-fungal and antitumor activities. Serves as a fluorescent DNA stain. Useful for the detection of protamine deficiency in sperm chromatin. The compound blocks macromolecule synthesis by a specific, reversible interaction with DNA in the presence of bivalent metal ions. Binding to DNA minor groove mediates an efficient competitive inhibition of DNA gyrase and significantly affects topoisomerase II activity.
Description (简体中文)
Biochem/physiol Actions
An antibiotic exhibiting anti-bacterial, anti-fungal and antitumor activities. Serves as a fluorescent DNA stain. Useful for the detection of protamine deficiency in sperm chromatin. The compound blocks macromolecule synthesis by a specific, reversible interaction with DNA in the presence of bivalent metal ions. Binding to DNA minor groove mediates an efficient competitive inhibition of DNA gyrase and significantly affects topoisomerase II activity.

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