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Niclosamide

Catalog No. N3510 Name Sigma Aldrich
CAS Number 50-65-7 Website http://www.sigmaaldrich.com
M. F. C13H8Cl2N2O4 Telephone 1-800-521-8956
M. W. 327.11962 Fax
Purity Email
Storage Chembase ID: 4480

SYNONYMS

Title
氯硝柳胺
IUPAC name
5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
IUPAC Traditional name
niclosamide
Synonyms
2′,5-二氯-4′-硝基水杨酸酰替苯胺
2′,5-Dichloro-4′-nitrosalicylanilide

DATABASE IDS

CAS Number 50-65-7
Beilstein Number 2820605
PubChem SID 24278585
EC Number 200-056-8
MDL Number MFCD00057597

PROPERTIES

Empirical Formula (Hill Notation) C13H8Cl2N2O4
GHS Pictograms GHS09
GHS Signal Word Warning
GHS Hazard statements H400
MSDS Link Download
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
GHS Precautionary statements P273
RID/ADR UN 3077 9/PG 3
RTECS VN8400000
Hazard Class 9
UN Number 3077
Packing Group 3
German water hazard class 2

DETAILS

Description (English)
Application
Niclosamide is a teniacide in the anthelmintic family. It is effective against cestodes that infect humans. Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It is used to inhibit the transcription and DNA binding of NF-κB in AML cells and ito induce apoptosis1.
Biochem/physiol Actions
Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It inhibits mitochondrial oxidative phosphorylation of parasitic helminths.
Niclosamide uncouples oxidative phosphorylation in the tapeworm. It inhibits mitochondrial oxidative phosphorylation of parasitic helminths. It inhibits the NF-κB pathway in acute myelogenous leukemia (AML) cells. Niclosamide inhibits the transcription and DNA binding of NF-κB. It blocks tumor necrosis factor-induced IκBα phosphorylation, translocation of p65, and expression of NF-κB- regulated genes in AML cells. It increases ROS levels to induce apoptosis in AML cells1.
Description (简体中文)
Application
Niclosamide is a teniacide in the anthelmintic family. It is effective against cestodes that infect humans. Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It is used to inhibit the transcription and DNA binding of NF-κB in AML cells and ito induce apoptosis1.
Biochem/physiol Actions
Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It inhibits mitochondrial oxidative phosphorylation of parasitic helminths.
Niclosamide uncouples oxidative phosphorylation in the tapeworm. It inhibits mitochondrial oxidative phosphorylation of parasitic helminths. It inhibits the NF-κB pathway in acute myelogenous leukemia (AML) cells. Niclosamide inhibits the transcription and DNA binding of NF-κB. It blocks tumor necrosis factor-induced IκBα phosphorylation, translocation of p65, and expression of NF-κB- regulated genes in AML cells. It increases ROS levels to induce apoptosis in AML cells1.

REFERENCES