Sulfaguanidine

• Catalog No.: S8751
• CAS Number: 57-67-0
• M. F.: C7H10N4O2S
• M. W.: 214.2449

SYNONYMS

• Title: 磺胺脒
• IUPAC name: 1-(4-aminobenzenesulfonyl)guanidine
• IUPAC Traditional name: aterian
• Synonyms: 4-氨基-N-脒基苯磺酰胺; 4-Amino-N-guanylbenzenesulfonamide; 4-氨基-N-(氨基亚氨基甲基)苯磺酰胺; 4-Amino-N-(aminoiminomethyl)benzenesulfonamide

DATABASE IDS

• PubChem SID: 24899810
• Beilstein Number: 2695326
• CAS Number: 57-67-0
• MDL Number: MFCD00038136
• EC Number: 200-345-9

PROPERTIES

• Empirical Formula (Hill Notation): C7H10N4O2S
• Gene Information: human ... F2(2147), PRSS1(5644)
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• RTECS: WO8575000
• Safety Statements: 26-36
• German water hazard class: 3

DETAILS

Description (English)

Application
Sulfaguanidine is used to block the synthesis of folic acid. It is used to study its effect on microsporidial growth and host cell viability2.
Biochem/physiol Actions
Sulfaguanidine is a sulfonamide antibiotic. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid1. Sulfaguanidine is a dihydrofolate reductase (DHFR) inhibitor. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Description (简体中文)

Application
Sulfaguanidine is used to block the synthesis of folic acid. It is used to study its effect on microsporidial growth and host cell viability2.
Biochem/physiol Actions
Sulfaguanidine is a sulfonamide antibiotic. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid1. Sulfaguanidine is a dihydrofolate reductase (DHFR) inhibitor. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.