N-Acetylneuraminic acid

• Catalog No.: A0812
• CAS Number: 131-48-6
• M. F.: C11H19NO9
• M. W.: 309.26986
• Purity: ≥95%

SYNONYMS

• Title: N-乙酰神经氨酸
• IUPAC name: (2S,4S,5R,6R)-5-acetamido-2,4-dihydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
• IUPAC Traditional name: β-neu5ac
• Synonyms: 醋纽拉酸; NANA; N-乙酰甘露糖胺丙酮酸; 5-Acetamido-3,5-dideoxy-D-glycero-D-galactononulosonic acid; NAN; Lactaminic acid; Sialic acid; 唾液酸

DATABASE IDS

• EC Number: 205-023-1
• MDL Number: MFCD00006620
• PubChem SID: 24890457
• CAS Number: 131-48-6
• Beilstein Number: 1716283

PROPERTIES

• Biological Source: synthetic
• Empirical Formula (Hill Notation): C11H19NO9
• Purity: ≥95%
• Type: Type IV-S
• GHS Signal Word: Warning
• GHS Hazard statements: H319
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• GHS Precautionary statements: P305 + P351 + P338
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Both sialic acid and neuraminic acid are loosely used to refer to conjugates of neuraminic acid. N-Acetylneuraminic acid is often found as the terminal sugar of cell surface glycoproteins. Cell surface glycoproteins have important roles in cell recognition and interaction as well as in cell adhesion. Membrane glycoproteins are also important in tumor growth and metastases.
Application
N-Acetylneuraminic acid (NANA, Neu5Ac) is a major component of glycoconjugates such as glycolipids, glycoproteins and proteoglycans (sialogylcoproteins) where it confers selective binding characteristics to the glycosylated component. Neu5Ac is used to study its biochemistry, metabolism and uptake in vivo and in vitro. Neu5Ac is used in the development of nanocarriers.

Description (简体中文)

Biochem/physiol Actions
唾液酸和神经氨酸通常都被宽泛地称为神经氨酸轭合物。研究发现，N-乙酰神经氨酸通常都是细胞表面糖蛋白的末端糖。细胞表面糖蛋白在细胞识别、细胞相互作用和细胞粘附方面都起到重要作用。膜糖蛋白也在肿瘤生长和转移中起重要作用。
Application
N-Acetylneuraminic acid (NANA, Neu5Ac) is a major component of glycoconjugates such as glycolipids, glycoproteins and proteoglycans (sialogylcoproteins) where it confers selective binding characteristics to the glycosylated component. Neu5Ac is used to study its biochemistry, metabolism and uptake in vivo and in vitro. Neu5Ac is used in the development of nanocarriers.