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4′-Chlorodiazepam_Molecular_structure_CAS_14439-61-3)
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4′-Chlorodiazepam

Catalog No. C5174 Name Sigma Aldrich
CAS Number 14439-61-3 Website http://www.sigmaaldrich.com
M. F. C16H12Cl2N2O Telephone 1-800-521-8956
M. W. 319.18528 Fax
Purity ≥98% (TLC) Email
Storage Chembase ID: 129289

SYNONYMS

IUPAC name
7-chloro-5-(4-chlorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
IUPAC Traditional name
4-chlorodiazepam
Synonyms
Ro 5-4864
Ro5-4864
7-Chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one

DATABASE IDS

PubChem SID 24892765
Beilstein Number 685202
CAS Number 14439-61-3
MDL Number MFCD00043406

PROPERTIES

Empirical Formula (Hill Notation) C16H12Cl2N2O
Purity ≥98% (TLC)
Gene Information rat ... Tspo(24230)
Solubility 2-hydroxypropyl-β-cyclodextrin: insoluble
Solubility H2O: insoluble
Drug Control regulated under CDSA - not available from Sigma-Aldrich Canada
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H302
European Hazard Symbols Harmful Harmful (Xn)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Risk Statements 22
RTECS DF0500000
Safety Statements 22-24/25
German water hazard class 3

DETAILS

Description (English)
Application
Peripheral benzodiazepine ligand useful in distinguishing central-type from peripheral-type benzodiazepine receptors.
Biochem/physiol Actions
4′-Chlorodiazepam (Ro5-4864) is a potent selective antagonist of the mitochondrial translocator protein 18kDa (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR). Ro5-4864 does not bind to GABA(A) receptors and lacks typical benzodiazepine effects, but has been found to be neuroprotective in several studies.
Description (简体中文)
Application
Peripheral benzodiazepine ligand useful in distinguishing central-type from peripheral-type benzodiazepine receptors.
Biochem/physiol Actions
4′-Chlorodiazepam (Ro5-4864) is a potent selective antagonist of the mitochondrial translocator protein 18kDa (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR). Ro5-4864 does not bind to GABA(A) receptors and lacks typical benzodiazepine effects, but has been found to be neuroprotective in several studies.

REFERENCES