Rutin hydrate

• Catalog No.: R5143
• CAS Number: 207671-50-9
• M. F.: C27H36O19
• M. W.: 664.56334
• Purity: ≥94% (HPLC)

SYNONYMS

• Title: 芦丁 水合物
• IUPAC name: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-4H-chromen-4-one trihydrate
• IUPAC Traditional name: troxerutin trihydrate
• Synonyms: Quercetin-3-rutinoside hydrate; Vitamin P 水合物; Vitamin P hydrate; Quercetin-3-rutinoside 水合物

DATABASE IDS

• MDL Number: MFCD00149490
• Beilstein Number: 75455
• EC Number: 205-814-1
• CAS Number: 207671-50-9
• PubChem SID: 24899379

PROPERTIES

• Empirical Formula (Hill Notation): C27H30O16 · xH2O
• Purity: ≥94% (HPLC)
• Apperance: yellow to green powder
• Melting Point: 195 °C (dec.)(lit.)
• Solubility: pyridine: soluble50 mg/mL
• Solubility: DMSO: soluble
• Solubility: aqueous base: soluble
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• Risk Statements: 22
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
A polyphenolic flavonoid that acts as an antioxidant and NO scavenger. It can attenuate peroxide production in glial cells by acting as a free radical scavenger and protect renal cells from oxidative injury. Inclusion of rutin in the diet of rats significantly reduced the appearance of single-strand breaks in nuclear DNA caused by hepatocarcinogens aflatoxin B1 and N-nitrosodimethylamine. This protection from DNA damage was found to be due to a reduction in the induction of repair enzymes polymerase, DNA polymerase β and DNA ligase. Since DNA damage and inefficient repair are thought to initiate the process of carcinogenesis, effects of rutin on these functions suggests a protective role of this flavonoid against carcinogenesis induced by chemical carcinogens.
Protocols & Applications
Ginkgo (Ginkgo biloba) Plant Profile: bioactives, mechanism of action, references

Description (简体中文)

Biochem/physiol Actions
A polyphenolic flavonoid that acts as an antioxidant and NO scavenger. It can attenuate peroxide production in glial cells by acting as a free radical scavenger and protect renal cells from oxidative injury. Inclusion of rutin in the diet of rats significantly reduced the appearance of single-strand breaks in nuclear DNA caused by hepatocarcinogens aflatoxin B1 and N-nitrosodimethylamine. This protection from DNA damage was found to be due to a reduction in the induction of repair enzymes polymerase, DNA polymerase β and DNA ligase. Since DNA damage and inefficient repair are thought to initiate the process of carcinogenesis, effects of rutin on these functions suggests a protective role of this flavonoid against carcinogenesis induced by chemical carcinogens.
Protocols & Applications
Ginkgo (Ginkgo biloba) Plant Profile: bioactives, mechanism of action, references