Z-Ile-Glu-Thr-Asp 7-amido-4-trifluoromethylcoumarin_Molecular_structure_CAS_219138-02-0)

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Z-Ile-Glu-Thr-Asp 7-amido-4-trifluoromethylcoumarin
Catalog No.	C5599	Name	Sigma Aldrich
CAS Number	219138-02-0	Website	http://www.sigmaaldrich.com
M. F.	C37H42F3N5O13	Telephone	1-800-521-8956
M. W.	821.7502896	Fax
Purity	≥95% (HPLC)	Email
Storage		Chembase ID: 155097

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SYNONYMS

IUPAC name

(4S)-4-[(2S,3S)-2-{[(benzyloxy)carbonyl]amino}-3-methylpentanamido]-4-{[(1S,2R)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-hydroxypropyl]carbamoyl}butanoic acid

IUPAC Traditional name

(4S)-4-[(2S,3S)-2-{[(benzyloxy)carbonyl]amino}-3-methylpentanamido]-4-{[(1S,2R)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-hydroxypropyl]carbamoyl}butanoic acid

Synonyms

Cbz-IETD-AFC

DATABASE IDS

MDL Number	MFCD01318832
CAS Number	219138-02-0

PROPERTIES

Empirical Formula (Hill Notation)	C37H42F3N5O13
Purity	≥95% (HPLC)
Gene Information	human ... CARD8(22900), CASP8(841), CASP8AP2(9994), CFLAR(8837), GZMB(3002)mouse ... CFLAR(117279), GZMB(171528)rat ... CASP8(12370), CFLAR(12633), GZMB(14939), RGD1561819(502004), RGD1562700(502007)
MSDS Link	Download
Personal Protective Equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage Temperature	-20°C
German water hazard class	3

DETAILS

Description (English)

Amino Acid Sequence
Z-Ile-Glu-Thr-Asp-AFC
Application
Fluorogenic substrate for caspase 8 and granzyme B.
Biochem/physiol Actions
IETD is the sequence of amino acid residues 172-175 of procaspase 3, which is cleaved during apoptosis to produce the p12 subunit and a p20 peptide that is further cleaved to form the p17 subunit of mature caspase 3.

Description (简体中文)