N-(2-Fluorenyl)acetamide

• Catalog No.: A7015
• CAS Number: 53-96-3
• M. F.: C15H13NO
• M. W.: 223.26982
• Purity: ≥90% (TLC)

SYNONYMS

• Title: N-(2-芴基)乙酰胺
• IUPAC name: N-(9H-fluoren-2-yl)acetamide
• IUPAC Traditional name: 2 acetylaminofluorene
• Synonyms: 2-AAF; N-乙酰基-2-氨基芴; 2-Acetamidofluorene; 2-乙酰氨基芴; N-Acetyl-2-aminofluorene

DATABASE IDS

• MDL Number: MFCD00001116
• EC Number: 200-188-6
• Beilstein Number: 2807677
• PubChem SID: 24891166
• CAS Number: 53-96-3

PROPERTIES

• Empirical Formula (Hill Notation): C15H13NO
• Purity: ≥90% (TLC)
• Apperance: off-white to brown
• Melting Point: 192-196 °C(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H350
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P308 + P313
• RID/ADR: UN 3077 9/PG 3
• Risk Statements: 45-22
• RTECS: AB9450000
• Safety Statements: 53-36/37/39-45
• Hazard Class: 9
• UN Number: 3077
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
A genotoxic carcinogen that is used to model liver carcinogenesis in rat. When N-hydroxylated by cytochrome CYP1A2 in the liver, 2-AAF forms adducts with DNA and is tumorigenic in liver and bladder.

Description (简体中文)

Biochem/physiol Actions
一种遗传毒性致癌物，用于诱发大鼠肝癌模型。当因肝脏中的细胞色素 CYP1A2 发生 N-羟基化时，2-AAF 与 DNA 形成加合物，在肝脏和膀胱中发生肿瘤。