ATPO

• Catalog No.: A7845
• CAS Number: 252930-37-3
• M. F.: C11H19N2O7P
• M. W.: 322.251521

SYNONYMS

• IUPAC name: 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-1,2-oxazol-4-yl]propanoic acid
• IUPAC Traditional name: 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-1,2-oxazol-4-yl]propanoic acid
• Synonyms: (R,S)-2-Amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid

DATABASE IDS

• PubChem SID: 24278239
• CAS Number: 252930-37-3
• MDL Number: MFCD03452828

PROPERTIES

• Empirical Formula (Hill Notation): C11H19N2O7P
• Gene Information: human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)rat ... Gria1(50592), Grik1(29559), Grin2a(24409)
• Apperance: solid
• Solubility: 1 M NaOH: soluble7 mg/mL
• Solubility: DMSO: insoluble
• Solubility: H2O: insoluble
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.
Application
The phosphono amino acid, (RS)-2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl+ ++]propio nic acid (ATPO) is a competitive antagonist at GluR1-4 (AMPA-preferring) receptors. ATPO is a structural hybrid between the NMDA antagonist (RS)-2-amino-7-phosphonoheptanoic acid (AP7) and the AMPA/GluR5 agonist, (RS)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid (ATPA).

Description (简体中文)

Biochem/physiol Actions
Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.
Application
The phosphono amino acid, (RS)-2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl+ ++]propio nic acid (ATPO) is a competitive antagonist at GluR1-4 (AMPA-preferring) receptors. ATPO is a structural hybrid between the NMDA antagonist (RS)-2-amino-7-phosphonoheptanoic acid (AP7) and the AMPA/GluR5 agonist, (RS)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid (ATPA).