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Chloramphenicol

Catalog No. C0378 Name Sigma Aldrich
CAS Number 56-75-7 Website http://www.sigmaaldrich.com
M. F. C11H12Cl2N2O5 Telephone 1-800-521-8956
M. W. 323.12938 Fax
Purity ≥98% (TLC) Email
Storage Chembase ID: 53504

SYNONYMS

Title
氯霉素
IUPAC name
2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
IUPAC Traditional name
chloromycetin
Synonyms
D(-)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide
D-(-)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol
D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide
D-(-)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide
Chloromycetin

DATABASE IDS

MDL Number MFCD00078159
Beilstein Number 2225532
PubChem SID 24892250
CAS Number 56-75-7
EC Number 200-287-4

PROPERTIES

Linear Formula Cl2CHCONHCH(CH2OH)CH(OH)C6H4NO2
Purity ≥98% (TLC)
Quality Level PREMIUM
Gene Information human ... CYP1A2(1544)
Melting Point 148-150 °C(lit.)
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H350
European Hazard Symbols Toxic Toxic (T)
MSDS Link Download
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements P201-P308 + P313
Risk Statements 45
RTECS AB6825000
Safety Statements 53-45
German water hazard class 3

DETAILS

Description (English)
Application
Used as a seletion agent for transformed cells containing chloramphenicol resistance genes.
Biochem/physiol Actions
Mode of Action: Inhibits translation on the 50S ribosomal subunit at the peptidyltransferase step (elongation inhibition). Bacteriostatic.Mode of Resistance: Acetylation by chloramphenicol acetyltransferase (cat gene).
Packaging
1 kg in poly bottle
5, 25, 100, 500 g in poly bottle
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information
Description (简体中文)
Application
Used as a seletion agent for transformed cells containing chloramphenicol resistance genes.
Biochem/physiol Actions
Mode of Action: Inhibits translation on the 50S ribosomal subunit at the peptidyltransferase step (elongation inhibition). Bacteriostatic.Mode of Resistance: Acetylation by chloramphenicol acetyltransferase (cat gene).
包装
1 kg in poly bottle
5, 25, 100, 500 g in poly bottle
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

REFERENCES