Wedelolactone

• Catalog No.: W4016
• CAS Number: 524-12-9
• M. F.: C16H10O7
• M. W.: 314.2464
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 3,13,14-trihydroxy-5-methoxy-8,17-dioxatetracyclo[8.7.0.0^2,^7.0^1^1,^1^6]heptadeca-1(10),2,4,6,11(16),12,14-heptaen-9-one
• IUPAC Traditional name: wedelolactone
• Synonyms: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one; 7-Methoxy-5,11,12-trihydroxycoumestan

DATABASE IDS

• MDL Number: MFCD07778564
• CAS Number: 524-12-9
• PubChem SID: 24724667

PROPERTIES

• Empirical Formula (Hill Notation): C16H10O7
• Purity: ≥98% (HPLC)
• Apperance: pale yellow solid
• Solubility: DMSO: soluble >10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H317
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P280
• Risk Statements: 22-43
• Safety Statements: 36/37
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Irreversible inhibitor of IKKα and β kinase activity (IC50 < 10 μM). Wedelolactone has no effects on p38 MAP kinase or Akt.

Description (简体中文)

Biochem/physiol Actions
Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Irreversible inhibitor of IKKα and β kinase activity (IC50 < 10 μM). Wedelolactone has no effects on p38 MAP kinase or Akt.