Rebeccamycin

• Catalog No.: R4900
• CAS Number: 93908-02-2
• M. F.: C27H21Cl2N3O7
• M. W.: 570.37754
• Purity: ≥98% (HPLC)
• Storage: protect from light

SYNONYMS

• IUPAC name: 5,21-dichloro-23-[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.0^2,^1^0.0^4,^9.0^1^1,^1^5.0^1^7,^2^2]tricosa-1(16),2(10),4,6,8,11(15),17(22),18,20-nonaene-12,14-dione
• IUPAC Traditional name: rebeccamycin

DATABASE IDS

• CAS Number: 93908-02-2
• MDL Number: MFCD01718312
• PubChem SID: 24899375

PROPERTIES

• Biological Source: from Saccharothrix aerocolonigenes
• Empirical Formula (Hill Notation): C27H21Cl2N3O7
• Purity: ≥98% (HPLC)
• Shipped in: wet ice
• Gene Information: human ... TOP1(7150)mouse ... Prkca(18750)rat ... Prkca(24680)
• Apperance: yellow solid
• Solubility: DMSO: ≥3 mg/mL
• Solubility: THF: soluble
• Storage Condition: protect from light
• Storage Temperature: -20°C
• German water hazard class: -

DETAILS

Description (English)

Biochem/physiol Actions
Rebeccamycin is an antibiotic composed of a halogenated indolocarbazole chromophore linked via N-glycosidic bond to a glucose derivative. As an antitumor agent,1 it is cytotoxic to tumor cell lines such as human lung adenocarcinoma, colon carcinoma and nasopharyngeal carcinoma, etc.2 Rebeccamycin intercalates into the DNA and is an inhibitor of topoisomerase I. It stabilizes the covalent topoisomerase I-DNA intermediate (the cleavable complex) resulting in increased DNA strand breaks.3

Description (简体中文)

Biochem/physiol Actions
Rebeccamycin is an antibiotic composed of a halogenated indolocarbazole chromophore linked via N-glycosidic bond to a glucose derivative. As an antitumor agent,1 it is cytotoxic to tumor cell lines such as human lung adenocarcinoma, colon carcinoma and nasopharyngeal carcinoma, etc.2 Rebeccamycin intercalates into the DNA and is an inhibitor of topoisomerase I. It stabilizes the covalent topoisomerase I-DNA intermediate (the cleavable complex) resulting in increased DNA strand breaks.3