UA62784

• Catalog No.: U3385
• CAS Number: 313367-92-9
• M. F.: C23H15NO3
• M. W.: 353.3701
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 4-[5-(4-methoxyphenyl)-1,3-oxazol-2-yl]-9H-fluoren-9-one
• IUPAC Traditional name: 4-[5-(4-methoxyphenyl)-1,3-oxazol-2-yl]fluoren-9-one
• Synonyms: 4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one

DATABASE IDS

• CAS Number: 313367-92-9
• MDL Number: MFCD00489199

PROPERTIES

• Empirical Formula (Hill Notation): C23H15NO3
• Purity: ≥98% (HPLC)
• Apperance: yellow powder
• Solubility: DMSO: >2 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Risk Statements: 22
• Storage Temperature: 2-8°C

DETAILS

Description (English)

Biochem/physiol Actions
UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.

Description (简体中文)

Biochem/physiol Actions
UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.