TN-16

• Catalog No.: T7580
• CAS Number: 33016-12-5
• M. F.: C19H18N2O2
• M. W.: 306.35842
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 5-benzyl-3-[1-(phenylamino)ethylidene]pyrrolidine-2,4-dione
• IUPAC Traditional name: 5-benzyl-3-[1-(phenylamino)ethylidene]pyrrolidine-2,4-dione
• Synonyms: 3-[1-(Phenylamino)ethylidene]-5-(phenylmethyl)-2,4-pyrrolidinedione; NSC 239274

DATABASE IDS

• CAS Number: 33016-12-5

PROPERTIES

• Empirical Formula (Hill Notation): C19H18N2O2
• Purity: ≥98% (HPLC)
• Apperance: white to tan powder
• Solubility: DMSO: ≥17 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H317-H400
• European Hazard Symbols: Irritant (Xi)
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P273-P280
• Risk Statements: 43-50/53
• Safety Statements: 36/37-60-61
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Inhibitor of microtubule assembly
TN-16 is a synthetic compound that blocks the assembly, and promotes the dissociation of microtubules. Recently, TN-16 has been shown to prevent the b-TrCP-mediated degradation of the transcription factor Gli2, leading to the up-regulation of BMP-2 and supporting a role for microtubule formation in the regulation of bone formation.

Description (简体中文)

Biochem/physiol Actions
Inhibitor of microtubule assembly
TN-16 is a synthetic compound that blocks the assembly, and promotes the dissociation of microtubules. Recently, TN-16 has been shown to prevent the b-TrCP-mediated degradation of the transcription factor Gli2, leading to the up-regulation of BMP-2 and supporting a role for microtubule formation in the regulation of bone formation.