A-967079

• Catalog No.: SML0085
• CAS Number: 1170613-55-4
• M. F.: C12H14FNO
• M. W.: 207.2440632
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: N-[1-(4-fluorophenyl)-2-methylpent-1-en-3-ylidene]hydroxylamine
• IUPAC Traditional name: N-[1-(4-fluorophenyl)-2-methylpent-1-en-3-ylidene]hydroxylamine
• Synonyms: (1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-penten-3-one oxime

DATABASE IDS

• CAS Number: 1170613-55-4
• MDL Number: MFCD20488058

PROPERTIES

• Empirical Formula (Hill Notation): C12H14FNO
• Purity: ≥98% (HPLC)
• Apperance: white to tan powder
• Solubility: DMSO: ≥12 mg/mL
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
A-967079 is a potent and selective antagonist of Transient Receptor Potential Anykrin 1 (TRPA1) with IC50′s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and minimal or no activity at other TRP channels or G-protein-coupled receptors, enzymes, transporters, and ion channels out of 89 tested. A-967079 blocks TRPA1 activation in human and rat cell lines and has been shown to reduce the responses of wide dynamic range (WDR) and nociceptive specific (NS) neurons to high-intensity mechanical stimulation.

Description (简体中文)

Biochem/physiol Actions
A-967079 is a potent and selective antagonist of Transient Receptor Potential Anykrin 1 (TRPA1) with IC50′s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and minimal or no activity at other TRP channels or G-protein-coupled receptors, enzymes, transporters, and ion channels out of 89 tested. A-967079 blocks TRPA1 activation in human and rat cell lines and has been shown to reduce the responses of wide dynamic range (WDR) and nociceptive specific (NS) neurons to high-intensity mechanical stimulation.