GPV574

• Catalog No.: SML0135
• CAS Number: 635703-12-7
• M. F.: C23H30N2O3
• M. W.: 382.4959
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 1-(4-{3-[4-(2,3-dimethylphenyl)piperazin-1-yl]-2-hydroxypropoxy}phenyl)ethan-1-one
• IUPAC Traditional name: 1-(4-{3-[4-(2,3-dimethylphenyl)piperazin-1-yl]-2-hydroxypropoxy}phenyl)ethanone
• Synonyms: 1-[4-[3-[4-(2,3-dimethylphenyl)-1-piperazinyl]-2-hydroxypropoxy]phenyl]-ethanone

DATABASE IDS

• CAS Number: 635703-12-7
• MDL Number: MFCD20527325

PROPERTIES

• Empirical Formula (Hill Notation): C23H30N2O3
• Purity: ≥98% (HPLC)
• Apperance: white to tan powder
• Solubility: DMSO: ≥10 mg/mL (warmed to 60°C)
• Storage Temperature: 2-8°C

DETAILS

Description (English)

Biochem/physiol Actions
GPV574 is a derivative of the Class 1C antiarrhythmic drug propafenone. GPV574 inhibits the delayed rectifier K+ channel HERG with similar affinity and time constant as propafenone (IC50 = 5 mM), but unlike the parent compound, does not remain permanently trapped in the channel pore. After wash-out of GPV574, channel activity is recovered within 60 seconds.

Description (简体中文)

Biochem/physiol Actions
GPV574 is a derivative of the Class 1C antiarrhythmic drug propafenone. GPV574 inhibits the delayed rectifier K+ channel HERG with similar affinity and time constant as propafenone (IC50 = 5 mM), but unlike the parent compound, does not remain permanently trapped in the channel pore. After wash-out of GPV574, channel activity is recovered within 60 seconds.