PF-477736

• Catalog No.: PZ0186
• CAS Number: 952021-60-2
• M. F.: C22H25N7O2
• M. W.: 419.4796
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (2R)-2-amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.0^4,^1^3]trideca-1,4(13),5,7,11-pentaen-6-yl]acetamide
• IUPAC Traditional name: (2R)-2-amino-2-cyclohexyl-N-[2-(1-methylpyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.0^4,^1^3]trideca-1,4(13),5,7,11-pentaen-6-yl]acetamide
• Synonyms: (2R)-2-Amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]-acetamide; PF-00477736

DATABASE IDS

• CAS Number: 952021-60-2
• MDL Number: MFCD16038847

PROPERTIES

• Empirical Formula (Hill Notation): C22H25N7O2
• Purity: ≥98% (HPLC)
• Apperance: yellow powder
• Solubility: DMSO: ≥20 mg/mL
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (简体中文)

Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
PF-00477736 is a potent, selective ATP-competitive small-molecule inhibitor that inhibits Chk1 with a Ki of 0.49 nM. The compound abrogates cell cycle arrest induced by DNA damage and enhances cytotoxicity of clinically important chemotherapeutic agents, including gemcitabine and carboplatin.

Description (English)

Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
PF-00477736 is a potent, selective ATP-competitive small-molecule inhibitor that inhibits Chk1 with a Ki of 0.49 nM. The compound abrogates cell cycle arrest induced by DNA damage and enhances cytotoxicity of clinically important chemotherapeutic agents, including gemcitabine and carboplatin.