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WZ811

Catalog No. SML0088 Name Sigma Aldrich
CAS Number 55778-02-4 Website http://www.sigmaaldrich.com
M. F. C18H18N4 Telephone 1-800-521-8956
M. W. 290.36232 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 155042

SYNONYMS

IUPAC name
N-[(4-{[(pyridin-2-yl)amino]methyl}phenyl)methyl]pyridin-2-amine
IUPAC Traditional name
N-({4-[(pyridin-2-ylamino)methyl]phenyl}methyl)pyridin-2-amine
Synonyms
N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

DATABASE IDS

MDL Number MFCD18086914
CAS Number 55778-02-4

PROPERTIES

Empirical Formula (Hill Notation) C18H18N4
Purity ≥98% (HPLC)
Apperance white to tan powder
Solubility DMSO: ≥7 mg/mL
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H302-H315-H319-H335
European Hazard Symbols Harmful Harmful (Xn)
MSDS Link Download
GHS Precautionary statements P261-P305 + P351 + P338
Risk Statements 22-36/37/38
Safety Statements 26
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
WZ811 is a potent, specific antagonist of CXCR4 (IC50 = 0.3 nM). WZ811 blocks SDF-1 mediated changes in cellular cAMP levels in U87 glioma cells (IC50 = 1.2 nM) and Matirgel infiltration of MDA-MB-231 cells (IC50 = 5.2 nM).
Description (简体中文)
Biochem/physiol Actions
WZ811 is a potent, specific antagonist of CXCR4 (IC50 = 0.3 nM). WZ811 blocks SDF-1 mediated changes in cellular cAMP levels in U87 glioma cells (IC50 = 1.2 nM) and Matirgel infiltration of MDA-MB-231 cells (IC50 = 5.2 nM).

REFERENCES