PDI inhibitor 16F16

• Catalog No.: SML0021
• CAS Number: 922507-80-0
• M. F.: C16H17ClN2O3
• M. W.: 320.77078
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: methyl 2-(2-chloroacetyl)-1-methyl-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-1-carboxylate
• IUPAC Traditional name: methyl 2-(2-chloroacetyl)-1-methyl-3H,4H,9H-pyrido[3,4-b]indole-1-carboxylate
• Synonyms: Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate; 2-(2-Chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-1-carboxylic acid methyl ester

DATABASE IDS

• MDL Number: MFCD20134198
• CAS Number: 922507-80-0

PROPERTIES

• Empirical Formula (Hill Notation): C16H17ClN2O3
• Purity: ≥98% (HPLC)
• Apperance: white to tan powder
• Solubility: DMSO: ≥12 mg/mL
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation.

Description (简体中文)

Biochem/physiol Actions
16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation.