Quinaprilat hydrate

• Catalog No.: Q0264
• CAS Number: 82768-85-2(anhydrous)
• M. F.: C23H28N2O6
• M. W.: 428.47822
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (3S)-2-[(2S)-2-{[(1S)-1-carboxy-3-phenylpropyl]amino}propanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrate
• IUPAC Traditional name: quinaprilat hydrate
• Synonyms: (3S)-2-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrate

DATABASE IDS

• CAS Number: 82768-85-2(anhydrous)
• MDL Number: MFCD08060097

PROPERTIES

• Empirical Formula (Hill Notation): C23H26N2O5 · xH2O
• Purity: ≥98% (HPLC)
• Apperance: white to tan powder
• Optical Rotation: [α]/D +16 to +23 ( C=1, MeOH)
• Solubility: DMSO: ≥23 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H400
• European Hazard Symbols: Toxic (T)
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P273-P301 + P310
• Risk Statements: 25-50
• Safety Statements: 45-61
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Quinaprilat is the active metabolite of Quinapril. It is an angiotensin converting enzyme (ACE) inhibitor, an antihypertensive used in treatment of congestive heart failure. Quinaprilat has high affinity to tissue ACE, and has been shown to improve impaired flow-dependent (endothelium-mediated) dilation (FDD) in patients with chronic heart failure compared to other ACE inhibitors with low affinity for tissue ACE.

Description (简体中文)

Biochem/physiol Actions
Quinaprilat is the active metabolite of Quinapril. It is an angiotensin converting enzyme (ACE) inhibitor, an antihypertensive used in treatment of congestive heart failure. Quinaprilat has high affinity to tissue ACE, and has been shown to improve impaired flow-dependent (endothelium-mediated) dilation (FDD) in patients with chronic heart failure compared to other ACE inhibitors with low affinity for tissue ACE.