Securinine

• Catalog No.: SML0055
• CAS Number: 5610-40-2
• M. F.: C13H15NO2
• M. W.: 217.2637
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (1S,2R,8S)-14-oxa-7-azatetracyclo[6.6.1.0^1,^1^1.0^2,^7]pentadeca-9,11-dien-13-one
• IUPAC Traditional name: (-)-securinine

DATABASE IDS

• MDL Number: MFCD00078775
• CAS Number: 5610-40-2

PROPERTIES

• Empirical Formula (Hill Notation): C13H15NO2
• Purity: ≥98% (HPLC)
• Apperance: yellow powder
• Optical Rotation: [α]/D -980 to -1015 ( C=1, MeOH)
• Solubility: DMSO: ≥25 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Risk Statements: 22
• RTECS: VS4115000
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Securinine is an alkaloid widely in traditional folk medicine. Long known as a GABAA antagonist, securinine was recently found to up-regulate p53 protein and to modulate the related family member p73 protein in a p53-dependent fashion, inducing p73 in the HCT116 p53(-) cells and down-regulating it in the p53(+) cells. Induction of proapoptotic protein p73 only in p53 cells could be used to target cancer cells preferentially. Securinine has been found to induce p53-independent, p73-dependent apoptosis in RKO colon cancer cells.

Description (简体中文)

Biochem/physiol Actions
Securinine is an alkaloid widely in traditional folk medicine. Long known as a GABAA antagonist, securinine was recently found to up-regulate p53 protein and to modulate the related family member p73 protein in a p53-dependent fashion, inducing p73 in the HCT116 p53(-) cells and down-regulating it in the p53(+) cells. Induction of proapoptotic protein p73 only in p53 cells could be used to target cancer cells preferentially. Securinine has been found to induce p53-independent, p73-dependent apoptosis in RKO colon cancer cells.