Safinamide mesylate salt

• Catalog No.: SML0025
• CAS Number: 202825-46-5
• M. F.: C18H23FN2O5S
• M. W.: 398.4490232
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl)amino]propanamide; methanesulfonic acid
• IUPAC Traditional name: methanesulfonic acid; safinamide
• Synonyms: (S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide; (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide; FCE-26743; PNU-151774E, NW-1015;

DATABASE IDS

• CAS Number: 202825-46-5
• MDL Number: MFCD15145475

PROPERTIES

• Empirical Formula (Hill Notation): C17H19FN2O2 · xCH4O3S
• Purity: ≥98% (HPLC)
• Apperance: white to tan powder
• Optical Rotation: [α]/D +9.5 to +14°, c = 1 (95% acetic acid)
• Solubility: H2O: ≥15 mg/mL
• Storage Temperature: 2-8°C

DETAILS

Description (English)

Biochem/physiol Actions
Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, safinamide is voltage-dependent sodium and calcium channel blocker. It appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals.

Description (简体中文)

Biochem/physiol Actions
Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, safinamide is voltage-dependent sodium and calcium channel blocker. It appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals.