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Safinamide mesylate salt_Molecular_structure_CAS_202825-46-5)
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Safinamide mesylate salt

Catalog No. SML0025 Name Sigma Aldrich
CAS Number 202825-46-5 Website http://www.sigmaaldrich.com
M. F. C18H23FN2O5S Telephone 1-800-521-8956
M. W. 398.4490232 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 72697

SYNONYMS

IUPAC name
(2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl)amino]propanamide; methanesulfonic acid
IUPAC Traditional name
methanesulfonic acid; safinamide
Synonyms
(S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide; (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide; FCE-26743; PNU-151774E, NW-1015;

DATABASE IDS

CAS Number 202825-46-5
MDL Number MFCD15145475

PROPERTIES

Empirical Formula (Hill Notation) C17H19FN2O2 · xCH4O3S
Purity ≥98% (HPLC)
Apperance white to tan powder
Optical Rotation [α]/D +9.5 to +14°, c = 1 (95% acetic acid)
Solubility H2O: ≥15 mg/mL
MSDS Link Download
Storage Temperature 2-8°C

DETAILS

Description (English)
Biochem/physiol Actions
Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, safinamide is voltage-dependent sodium and calcium channel blocker. It appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals.
Description (简体中文)
Biochem/physiol Actions
Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, safinamide is voltage-dependent sodium and calcium channel blocker. It appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals.

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