L 748337 hydrate

• Catalog No.: L7045
• M. F.: C26H33N3O6S
• M. W.: 515.62172
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: N-({3-[(2S)-3-{[2-(4-benzenesulfonamidophenyl)ethyl]amino}-2-hydroxypropoxy]phenyl}methyl)acetamide hydrate
• IUPAC Traditional name: N-({3-[(2S)-3-{[2-(4-benzenesulfonamidophenyl)ethyl]amino}-2-hydroxypropoxy]phenyl}methyl)acetamide hydrate
• Synonyms: N-(3-{3-[2-(4-Benzenesulfonylamino-phenyl)-ethylamino]-(2S)-2-hydroxy-propoxy}-benzyl)-acetamide hydrate; Acetamide, N-[[3-[(2S)-2-hydroxy-3-[[2-[4-[(phenylsulfonyl)amino]phenyl]ethyl]amino]propoxy]phenyl]methyl] hydrate

DATABASE IDS

• MDL Number: MFCD20134197

PROPERTIES

• Empirical Formula (Hill Notation): C26H31N3O5S · xH2O
• Purity: ≥98% (HPLC)
• Apperance: powder
• Optical Rotation: [α]/D +4.0 to +8.0°, c = 4 in DMSO
• Solubility: DMSO: >12 mg/mL
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
L 748337 is a selective, competitive beta 3 adrenergic receptor antagonist, that binds to the receptor with an affinity of 04 nM. The affinities for beta-1 and beta-2 receptors are 154 and 204 nM, respectively. The compound potently inhibits agonist-stimulated lipolysis in adipocytes, as well as agonist induced relaxation of smooth muscle.

Description (简体中文)

Biochem/physiol Actions
L 748337 is a selective, competitive beta 3 adrenergic receptor antagonist, that binds to the receptor with an affinity of 04 nM. The affinities for beta-1 and beta-2 receptors are 154 and 204 nM, respectively. The compound potently inhibits agonist-stimulated lipolysis in adipocytes, as well as agonist induced relaxation of smooth muscle.