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ICI 192605_Molecular_structure_CAS_117621-64-4)
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ICI 192605

Catalog No. I2536 Name Sigma Aldrich
CAS Number 117621-64-4 Website http://www.sigmaaldrich.com
M. F. C22H23ClO5 Telephone 1-800-521-8956
M. W. 402.86802 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 155027

SYNONYMS

IUPAC name
6-[(2R,4R,5S)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]hex-4-enoic acid
IUPAC Traditional name
6-[(2R,4R,5S)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]hex-4-enoic acid
Synonyms
6-[(2R,4R,5S)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]-
4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl) hexenoic acid
4-Hexenoic acid
(4Z)-rel-

DATABASE IDS

CAS Number 117621-64-4
MDL Number MFCD00673936

PROPERTIES

Empirical Formula (Hill Notation) C22H23ClO5
Purity ≥98% (HPLC)
Apperance white to tan powder
Solubility DMSO: ≥20 mg/mL
GHS Pictograms GHS07
GHS Pictograms GHS09
GHS Signal Word Warning
GHS Hazard statements H302-H410
European Hazard Symbols Harmful Harmful (Xn)
European Hazard Symbols Nature polluting Nature polluting (N)
MSDS Link Download
GHS Precautionary statements P273-P501
Risk Statements 22-50/53
Safety Statements 60-61
Storage Temperature -20°C
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
ICI 192605 is a potent thromboxane A2 receptor antagonist. It inhibits platelet aggregation and can reverse the effects of vasoconstrictors such as TXA2 or PGD2. ICI 192605 can reverse vasoconstriction induced by inhibition of NO production by L-NEMA, which leads to an increase in TXA2 release.
Description (简体中文)
Biochem/physiol Actions
ICI 192605 is a potent thromboxane A2 receptor antagonist. It inhibits platelet aggregation and can reverse the effects of vasoconstrictors such as TXA2 or PGD2. ICI 192605 can reverse vasoconstriction induced by inhibition of NO production by L-NEMA, which leads to an increase in TXA2 release.

REFERENCES