NSC 668036 hydrate

• Catalog No.: SML0046
• CAS Number: 144678-63-7(anhydrous)
• M. F.: C21H38N2O10
• M. W.: 478.53382
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (2S)-2-{[(2S)-2-[(2S)-2-{[(2S)-2-{[(tert-butoxy)carbonyl]amino}propanoyl]oxy}-3-methylbutanamido]propanoyl]oxy}-3-methylbutanoic acid hydrate
• IUPAC Traditional name: (2S)-2-{[(2S)-2-[(2S)-2-{[(2S)-2-[(tert-butoxycarbonyl)amino]propanoyl]oxy}-3-methylbutanamido]propanoyl]oxy}-3-methylbutanoic acid hydrate
• Synonyms: N-[(1,1-Dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-alanyl-(2S)-2-hydroxy-3-methylbutanoic acid hydrate; N-[(1,1-Dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-Alanine-(1S)-1-carboxy-2-methylpropyl ester hydrate

DATABASE IDS

• CAS Number: 144678-63-7(anhydrous)
• MDL Number: MFCD20036264

PROPERTIES

• Empirical Formula (Hill Notation): C21H36N2O9 · xH2O
• Purity: ≥98% (HPLC)
• Shipped in: wet ice
• Apperance: white to tan powder
• Solubility: H2O: ≥5 mg/mL
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
NSC 668036 binds to the PDZ domain of the Wnt-pathway signaling molecule Disheveled (Dvl), blocking the binding and activation of Dvl by Frizzled. In Xenopus embryos, NSC 668036 inhibited Wnt3A-induced expression of the target gene Siamois and formation of secondary axes.

Description (简体中文)

Biochem/physiol Actions
NSC 668036 binds to the PDZ domain of the Wnt-pathway signaling molecule Disheveled (Dvl), blocking the binding and activation of Dvl by Frizzled. In Xenopus embryos, NSC 668036 inhibited Wnt3A-induced expression of the target gene Siamois and formation of secondary axes.