Ac-PGP trifluoroacetate salt hydrate

• Catalog No.: A2112
• CAS Number: 292171-04-1(freebase)
• M. F.: C16H24F3N3O8
• M. W.: 443.3722696
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (2S)-1-(2-{[(2S)-1-acetylpyrrolidin-2-yl]formamido}acetyl)pyrrolidine-2-carboxylic acid trifluoroacetic acid hydrate
• IUPAC Traditional name: (2S)-1-(2-{[(2S)-1-acetylpyrrolidin-2-yl]formamido}acetyl)pyrrolidine-2-carboxylic acid trifluoroacetic acid hydrate
• Synonyms: Acetyl Pro-Gly-Pro; Acetyl-proline-glycine-proline; 1-Acetyl-L-prolylglycyl-L-proline; N-α-PGP; acPGP

DATABASE IDS

• CAS Number: 292171-04-1(freebase)
• MDL Number: MFCD20134196

PROPERTIES

• Empirical Formula (Hill Notation): C14H21N3O5 · xC2HF3O2 · yH2O
• Purity: ≥98% (HPLC)
• Shipped in: wet ice
• Apperance: white to tan powder
• Solubility: deionized water: ≥2 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Risk Statements: 22
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
N-acetyl Proline-Glycine-Proline (ac-PGP) is a potent and selective neutrophil chemoattractant. It is generated enzymatically from extracellular matrix proteins such as collagen. PGP is generated from native collagen by the action of matrix metalloproteinase-8 (MMP-8) and/or MMP-9, followed by a secondary cleavage by prolyl endopeptidase (PE). N-terminal acetylation of PGP (Ac-PGP) occurs through an unknown mechanism. Both PGP and AcPGP are considered biomarkers and possible therapeutic targets for chronic obstructive pulmonary disease (COPD) and may also be markers for acute pulmonary exacerbation in Cystic Fibrosis.

Description (简体中文)

Biochem/physiol Actions
N-acetyl Proline-Glycine-Proline (ac-PGP) is a potent and selective neutrophil chemoattractant. It is generated enzymatically from extracellular matrix proteins such as collagen. PGP is generated from native collagen by the action of matrix metalloproteinase-8 (MMP-8) and/or MMP-9, followed by a secondary cleavage by prolyl endopeptidase (PE). N-terminal acetylation of PGP (Ac-PGP) occurs through an unknown mechanism. Both PGP and AcPGP are considered biomarkers and possible therapeutic targets for chronic obstructive pulmonary disease (COPD) and may also be markers for acute pulmonary exacerbation in Cystic Fibrosis.