FR-171113

• Catalog No.: SML0028
• CAS Number: 173904-50-2
• M. F.: C19H11Cl3N2O4S
• M. W.: 469.72564
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: methyl 2-[3-(4-chlorophenyl)-2-(2,4-dichlorobenzamido)-4-oxo-1,3-thiazolidin-5-ylidene]acetate
• IUPAC Traditional name: methyl 2-[3-(4-chlorophenyl)-2-(2,4-dichlorobenzamido)-4-oxo-1,3-thiazolidin-5-ylidene]acetate
• Synonyms: FR-171113; 2-[3-(4-chlorophenyl)-2-[(2,4-dichlorobenzoyl)imino]-4-oxo-5-thiazolidinylidene]-acetic acid, methyl ester

DATABASE IDS

• CAS Number: 173904-50-2

PROPERTIES

• Empirical Formula (Hill Notation): C19H11Cl3N2O4S
• Purity: ≥98% (HPLC)
• Apperance: powder
• Solubility: DMSO: ≥5 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H410
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P273-P501
• Risk Statements: 50/53
• Safety Statements: 60-61
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
FR171113 was the first non-peptide antagonist of the Protease Activated Receptor-1 (PAR1), also termed thrombin receptor. FR171113 inhibits either thrombin or TRAP-6-induced platelet aggregation (IC50 = 290 and 150 nM, respectively). The compound does not affect the protease activity of thrombin or clotting time.

Description (简体中文)

Biochem/physiol Actions
FR171113 was the first non-peptide antagonist of the Protease Activated Receptor-1 (PAR1), also termed thrombin receptor. FR171113 inhibits either thrombin or TRAP-6-induced platelet aggregation (IC50 = 290 and 150 nM, respectively). The compound does not affect the protease activity of thrombin or clotting time.