Auraptene

• Catalog No.: A9861
• CAS Number: 495-02-3
• M. F.: C19H22O3
• M. W.: 298.37618
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 7-[(3,7-dimethylocta-2,6-dien-1-yl)oxy]-2H-chromen-2-one
• IUPAC Traditional name: 7-[(3,7-dimethylocta-2,6-dien-1-yl)oxy]chromen-2-one
• Synonyms: 7-Geranyloxycoumarin; 7-[[(2E)-3,7-dimethyl-2,6-octadien-1-yl]oxy]-2H-1-benzopyran-2-one; Aurapten

DATABASE IDS

• CAS Number: 495-02-3
• MDL Number: MFCD00075948

PROPERTIES

• Empirical Formula (Hill Notation): C19H22O3
• Purity: ≥98% (HPLC)
• Apperance: white to off-white powder
• Solubility: DMSO: >20 mg/mL
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (简体中文)

Biochem/physiol Actions
Auraptene is an estrogen receptor modulator that also acts as an ACAT inhibitor. It displays anti-tumor effects in several xenograft and chemically-induced murine tumor models. Auraptene induces apoptosis and is anti-proliferative in cancer cell lines. It has agonistic properties against PPARs, and interferes with lipid and cholesterol production by inhibiting ACAT (IC50 = 4 uM).

Description (English)

Biochem/physiol Actions
Auraptene is an estrogen receptor modulator that also acts as an ACAT inhibitor. It displays anti-tumor effects in several xenograft and chemically-induced murine tumor models. Auraptene induces apoptosis and is anti-proliferative in cancer cell lines. It has agonistic properties against PPARs, and interferes with lipid and cholesterol production by inhibiting ACAT (IC50 = 4 uM).