Doramectin synthetic

• Catalog No.: D6696
• CAS Number: 117704-25-3
• M. F.: C50H74O14
• M. W.: 899.11416
• Purity: ≥90%

SYNONYMS

• Title: 多拉克汀 合成的
• IUPAC name: (1'R,2S,4'S,5S,6R,12'S,13'S,20'R,21'R,24'S)-6-cyclohexyl-21',24'-dihydroxy-12'-{[(2S,4S,5S,6S)-5-{[(2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-5,6-dihydro-3',7',19'-trioxaspiro[pyran-2,6'-tetracyclo[15.6.1.1^4,^8.0^2^0,^2^4]pentacosane]-10',14',16',22'-tetraen-2'-one
• IUPAC Traditional name: (1'R,2S,4'S,5S,6R,12'S,13'S,20'R,21'R,24'S)-6-cyclohexyl-21',24'-dihydroxy-12'-{[(2S,4S,5S,6S)-5-{[(2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-5,6-dihydro-3',7',19'-trioxaspiro[pyran-2,6'-tetracyclo[15.6.1.1^4,^8.0^2^0,^2^4]pentacosane]-10',14',16',22'-tetraen-2'-one
• Synonyms: 25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin; 多拉克汀; Doramectin; 25-环己基-5-O-去甲基-25-去(1-甲基丙基)阿维菌素

DATABASE IDS

• CAS Number: 117704-25-3
• MDL Number: MFCD00894747

PROPERTIES

• Biological Source: from synthetic
• Empirical Formula (Hill Notation): C50H74O14
• Impurities: ≤5% water (Karl Fischer)
• Purity: ≥90%
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H410
• European Hazard Symbols: Toxic (T)
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P273-P301 + P310-P501
• Risk Statements: 25-50/53
• Safety Statements: 33-45-60-61
• German water hazard class: 3

DETAILS

Description (English)

Application
Doramectin is commonly used in veterinary medicine for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites. It is effective against Haemonchus spp., Ostertagia spp., Trichostrongylus spp., Cooperia spp., Oesophagostomum spp., Dyctiocaulus viviparus, Dermatobia hominis, Boophilus microplus, Psoroptes bovis, as well as other internal and external parasites1,2.
Biochem/physiol Actions
Doramectin is a derivative of ivermectin. It is thought to work like other macrocyclic lactones by opening glutamate-gated chloride channels in the nerve cells, causing paralysis.

Description (简体中文)

Application
Doramectin is commonly used in veterinary medicine for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites. It is effective against Haemonchus spp., Ostertagia spp., Trichostrongylus spp., Cooperia spp., Oesophagostomum spp., Dyctiocaulus viviparus, Dermatobia hominis, Boophilus microplus, Psoroptes bovis, as well as other internal and external parasites1,2.
Biochem/physiol Actions
Doramectin is a derivative of ivermectin. It is thought to work like other macrocyclic lactones by opening glutamate-gated chloride channels in the nerve cells, causing paralysis.