KB-R7943

• Catalog No.: K4144
• CAS Number: 182004-64-4(freebase)
• M. F.: C17H21N3O6S2
• M. W.: 427.49514
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: [(2-{4-[(4-nitrophenyl)methoxy]phenyl}ethyl)sulfanyl]methanimidamide; methanesulfonic acid
• IUPAC Traditional name: (2-{4-[(4-nitrophenyl)methoxy]phenyl}ethyl)sulfanylmethanimidamide; methanesulfonic acid
• Synonyms: 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester, methanesulfonate (1:1); Carbamimidothioic acid

DATABASE IDS

• MDL Number: MFCD00952138
• CAS Number: 182004-64-4(freebase)

PROPERTIES

• Empirical Formula (Hill Notation): C16H17N3O3S·CH3SO3H
• Purity: ≥98% (HPLC)
• Apperance: off-white to tan powder
• Solubility: DMSO: >10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H400
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P273
• Risk Statements: 50
• Safety Statements: 61
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
KB-R7943 inhibits the reversed Na(+)/Ca(2+) exchanger, NCX. In cardiomyocytes, Ca2+ is released from intracellular stores during contraction, and sequestered again during relaxation. NCX is the primary mechanism that prevents Ca2+ overload due to influx of calcium across the plasma membrane.

Description (简体中文)

Biochem/physiol Actions
KB-R7943 inhibits the reversed Na(+)/Ca(2+) exchanger, NCX. In cardiomyocytes, Ca2+ is released from intracellular stores during contraction, and sequestered again during relaxation. NCX is the primary mechanism that prevents Ca2+ overload due to influx of calcium across the plasma membrane.