SR8278

• Catalog No.: S9576
• CAS Number: 1254944-66-5
• M. F.: C18H19NO3S2
• M. W.: 361.47836
• Purity: ≥98%

SYNONYMS

• IUPAC name: ethyl 2-[5-(methylsulfanyl)thiophene-2-carbonyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
• IUPAC Traditional name: ethyl 2-[5-(methylsulfanyl)thiophene-2-carbonyl]-3,4-dihydro-1H-isoquinoline-3-carboxylate
• Synonyms: 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester

DATABASE IDS

• CAS Number: 1254944-66-5
• MDL Number: MFCD18782736

PROPERTIES

• Empirical Formula (Hill Notation): C18H19NO3S2
• Purity: ≥98%
• Apperance: white to tan semisolid
• Solubility: DMSO: ≥30 mg/mL
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
SR8278 is a Nuclear Heme Receptor REV-ERB antagonist. REV-ERBα plays a critical role in regulation of the circadian rhythm by repressing target gene activities. Additionally, REV-ERBα has been shown to regulate metabolic processes including lipid and glucose metabolism. SR8278 blocks the ability of the synthetic agonist GSK4112 to enhance REV-ERBα-dependent repression and stimulates the expression of REV-ERBα target genes involved in gluconeogenesis.

Description (简体中文)

Biochem/physiol Actions
SR8278 is a Nuclear Heme Receptor REV-ERB antagonist. REV-ERBα plays a critical role in regulation of the circadian rhythm by repressing target gene activities. Additionally, REV-ERBα has been shown to regulate metabolic processes including lipid and glucose metabolism. SR8278 blocks the ability of the synthetic agonist GSK4112 to enhance REV-ERBα-dependent repression and stimulates the expression of REV-ERBα target genes involved in gluconeogenesis.