RS-127445 hydrochloride

• Catalog No.: R2533
• CAS Number: 199864-86-3
• M. F.: C17H17ClFN3
• M. W.: 317.7883832
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 4-(4-fluoronaphthalen-1-yl)-6-(propan-2-yl)pyrimidin-2-amine hydrochloride
• IUPAC Traditional name: 4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2-amine hydrochloride
• Synonyms: 2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine hydrochloride

DATABASE IDS

• MDL Number: MFCD11112196
• CAS Number: 199864-86-3

PROPERTIES

• Empirical Formula (Hill Notation): C17H16FN3 · HCl
• Purity: ≥98% (HPLC)
• Apperance: white to tan powder
• Solubility: DMSO: ≥20 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H315-H319-H335
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P261-P301 + P310-P305 + P351 + P338
• Risk Statements: 25-36
• Safety Statements: 26-45
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.

Description (简体中文)

Biochem/physiol Actions
RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.