VU0357121

• Catalog No.: SML0019
• CAS Number: 433967-28-3
• M. F.: C17H17F2NO2
• M. W.: 305.3191864
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 4-butoxy-N-(2,4-difluorophenyl)benzamide
• IUPAC Traditional name: 4-butoxy-N-(2,4-difluorophenyl)benzamide
• Synonyms: VU0357121; 4-Butoxy-N-(2,4-difluorophenyl)-benzamide

DATABASE IDS

• CAS Number: 433967-28-3
• MDL Number: MFCD03243692

PROPERTIES

• Empirical Formula (Hill Notation): C17H17F2NO2
• Purity: ≥98% (HPLC)
• Apperance: powder
• Solubility: DMSO: ≥18 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H410
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P273-P501
• Risk Statements: 50/53
• Safety Statements: 60-61
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
VU0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax. Its site of action is distinct from the classical mGlu5 negative allosteric modulator (NAM) MPEP allosteric site or the site of a recetly discovered PAM, CPPHA. However, VU0357121shares a functional interaction with the MPEP site. VU0357121 is highly selective for activation of mGlu5 and is inactive or very weakly antagonizing at other mGlu receptor subtypes.

Description (简体中文)

Biochem/physiol Actions
VU0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax. Its site of action is distinct from the classical mGlu5 negative allosteric modulator (NAM) MPEP allosteric site or the site of a recetly discovered PAM, CPPHA. However, VU0357121shares a functional interaction with the MPEP site. VU0357121 is highly selective for activation of mGlu5 and is inactive or very weakly antagonizing at other mGlu receptor subtypes.