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6-Thioguanine

Catalog No. A4660 Name Sigma Aldrich
CAS Number 154-42-7 Website http://www.sigmaaldrich.com
M. F. C5H5N5S Telephone 1-800-521-8956
M. W. 167.1917 Fax
Purity ~98% Email
Storage Chembase ID: 102918

SYNONYMS

Title
6-硫鸟嘌呤
IUPAC name
2-amino-6,7-dihydro-1H-purine-6-thione
IUPAC Traditional name
2-aminopurine-6(1h)-thione
Synonyms
2-氨基-6-巯嘌呤
2-Amino-6-purinethiol
2-Amino-6-mercaptopurine
2-氨基-6巯基嘌呤

DATABASE IDS

CAS Number 154-42-7
Beilstein Number 157765
PubChem SID 24890892
MDL Number MFCD00233553
EC Number 205-827-2

PROPERTIES

RID/ADR UN 2811 6.1/PG 3
Risk Statements 25
RTECS UP0740000
Safety Statements 28-36/37/39-45
Hazard Class 6.1
UN Number 2811
Packing Group 3
German water hazard class 3
GHS Pictograms GHS06
GHS Signal Word Danger
GHS Hazard statements H301
European Hazard Symbols Toxic Toxic (T)
MSDS Link Download
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
GHS Precautionary statements P301 + P310
Concentration 50 ×
Empirical Formula (Hill Notation) C5H5N5S
Grade Hybri-Max™
Impurities endotoxin, tested
Product Line BioXtra
Purity ~98%
Sterility γ-irradiated
Suitability suitable for hybridoma
Apperance lyophilized powder
Melting Point ≥300 °C(lit.)

DETAILS

Description (English)
Application
Used in hybridoma formation applications as a selection agent.
Reconstitution
Reconstitute contents of vial with 10 ml sterile cell culture medium. Stock solution is sufficient to prepare 500 ml medium. Final working concentration: 30 μM 2-amino-6-mercaptopurine.
Biochem/physiol Actions
Ribosylated and phosphorylated by the same pathway as natural purine bases; as the nucleotide, inhibits a variety of cellular processes involved in nucleic acid synthesis. Has a long history as an effective treatment of leukemia.1
Legal Information
Hybri-Max is a trademark of Sigma-Aldrich Co. LLC
Description (简体中文)
Application
在杂交瘤形成应用中作为选择剂。
Reconstitution
10mL 无菌细胞培养基可复原一小瓶本品。储存液足以制备 500mL 培养基。最终工作浓度:30μM 2-氨基-6-巯基嘌呤。
Biochem/physiol Actions
Ribosylated and phosphorylated by the same pathway as natural purine bases; as the nucleotide, inhibits a variety of cellular processes involved in nucleic acid synthesis. Has a long history as an effective treatment of leukemia.1
法律信息
Hybri-Max 商标 Sigma-Aldrich Co. LLC

REFERENCES