Letrozole

• Catalog No.: L6545
• CAS Number: 112809-51-5
• M. F.: C17H11N5
• M. W.: 285.30274
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 4-[(4-cyanophenyl)(1H-1,2,4-triazol-1-yl)methyl]benzonitrile
• IUPAC Traditional name: letrozole
• Synonyms: 4,4′-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile

DATABASE IDS

• MDL Number: MFCD00866241
• CAS Number: 112809-51-5

PROPERTIES

• Empirical Formula (Hill Notation): C17H11N5
• Purity: ≥98% (HPLC)
• Apperance: white to off-white powder
• Solubility: DMSO: >50 mg/mL
• RTECS: DI4957000
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Letrozole is a third generation nonsteroidal aromatase inhibitor. It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of androgens to estrogens. Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues.

Description (简体中文)

Biochem/physiol Actions
Letrozole is a third generation nonsteroidal aromatase inhibitor. It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of androgens to estrogens. Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues.