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Rosiglitazone

Catalog No. R2408 Name Sigma Aldrich
CAS Number 122320-73-4 Website http://www.sigmaaldrich.com
M. F. C18H19N3O3S Telephone 1-800-521-8956
M. W. 357.42676 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 295

SYNONYMS

IUPAC name
5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)methyl]-1,3-thiazolidine-2,4-dione
IUPAC Traditional name
rosiglitazone
Synonyms
rosiglitazone
5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione

DATABASE IDS

MDL Number MFCD00871760
CAS Number 122320-73-4

PROPERTIES

Linear Formula C18H19N3O3S
Purity ≥98% (HPLC)
Purity ≥98% (HPLC)
Apperance powder
Solubility DMSO: ≥10 mg/mL
MSDS Link Download
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Rosiglitazone is a potent agonist for PPARγ with an EC50 of 43 nM for the human receptor. It is antidiabetic, working as an insulin sensitizer by binding to the PPARγ receptors in fat cells and making the cells more responsive to insulin.
Description (简体中文)
Biochem/physiol Actions
Rosiglitazone is a potent agonist for PPARγ with an EC50 of 43 nM for the human receptor. It is antidiabetic, working as an insulin sensitizer by binding to the PPARγ receptors in fat cells and making the cells more responsive to insulin.

REFERENCES