PX 12

• Catalog No.: M5324
• CAS Number: 141400-58-0
• M. F.: C7H12N2S2
• M. W.: 188.31358
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-(butan-2-yldisulfanyl)-1H-imidazole
• IUPAC Traditional name: 2-(sec-butyldisulfanyl)-1H-imidazole
• Synonyms: 2-[(1-methylpropyl)dithio]-1H-imidazole

DATABASE IDS

• MDL Number: MFCD18086851
• CAS Number: 141400-58-0

PROPERTIES

• Safety Statements: 26
• Storage Temperature: 2-8°C
• German water hazard class: 3
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Empirical Formula (Hill Notation): C7H12N2S2
• Purity: ≥98% (HPLC)
• Apperance: off-white to tan powder
• Solubility: DMSO: >25 mg/mL

DETAILS

Description (English)

Biochem/physiol Actions
PX-12 inhibits the thioredoxin redox system and HIF-1a activity. PX 12 inhibits hypoxia-induced HIF-1a transcriptional activity (IC50 11 nM) and proliferation of HT29 and MCF-7 tumor cells (IC50 1.9 and 0.9 uM, respectively).

Description (简体中文)

Biochem/physiol Actions
PX-12 inhibits the thioredoxin redox system and HIF-1a activity. PX 12 inhibits hypoxia-induced HIF-1a transcriptional activity (IC50 11 nM) and proliferation of HT29 and MCF-7 tumor cells (IC50 1.9 and 0.9 uM, respectively).