116-9e

• Catalog No.: E1036
• CAS Number: 831217-43-7
• M. F.: C31H32N2O5
• M. W.: 512.59618
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 6-{5-[(benzyloxy)carbonyl]-6-methyl-2-oxo-4-(4-phenylphenyl)-1,2,3,4-tetrahydropyrimidin-1-yl}hexanoic acid
• IUPAC Traditional name: 6-{5-[(benzyloxy)carbonyl]-6-methyl-2-oxo-4-(4-phenylphenyl)-3,4-dihydropyrimidin-1-yl}hexanoic acid
• Synonyms: 4-[1,1′-Biphenyl]-4-yl-3,4-dihydro-6-methyl-2-oxo-5-[(phenylmethoxy)carbonyl]-1(2H)-pyrimidinehexanoic acid; 116-9e

DATABASE IDS

• MDL Number: MFCD18632539
• CAS Number: 831217-43-7

PROPERTIES

• Empirical Formula (Hill Notation): C31H32N2O5
• Purity: ≥98% (HPLC)
• Apperance: white to off-white powder
• Solubility: DMSO: >20 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H410
• European Hazard Symbols: Toxic (T)
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P273-P301 + P310-P501
• Risk Statements: 25-50/53
• Safety Statements: 45-60-61
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (简体中文)

Biochem/physiol Actions
116-9e is a blocker of Hsp40-Hsp70 binding thereby inhibiting the chaperone activity of Hsp70-Hsp40. The Hsp40 family of co-chaperones binds to Hsp70 through a conserved J-domain. It is believed that 116-9e inhibits chaperone functions by preventing Hsp70-Hsp40 complex assembly.The same compound by a different name, MAL2-11B, has been found to inhibit the activity of a viral J-domain protein, large tumor antigen (TAg). MAL2-11B inhibited both TAg’s endogenous ATPase activity and the TAg-mediated activation of Hsp70.

Description (English)

Biochem/physiol Actions
116-9e is a blocker of Hsp40-Hsp70 binding thereby inhibiting the chaperone activity of Hsp70-Hsp40. The Hsp40 family of co-chaperones binds to Hsp70 through a conserved J-domain. It is believed that 116-9e inhibits chaperone functions by preventing Hsp70-Hsp40 complex assembly.The same compound by a different name, MAL2-11B, has been found to inhibit the activity of a viral J-domain protein, large tumor antigen (TAg). MAL2-11B inhibited both TAg’s endogenous ATPase activity and the TAg-mediated activation of Hsp70.